Opening Lecture:
 First Tudor Griffith
 Memorial Lecture

Preliminary program (Last update 8 June, 2012)
Wednesday June 27th:
20h30 - 20h45 Welcoming Remarks:
EDHF: past and present
Paul M. Vanhoutte
  First Tudor Griffith lecture session
Chair: Paul M Vanhoutte
20h45 - 21h30 First Tudor Griffith lecture:
Tudor Griffith, gap junctions and conducted vasodilation: electromechanical coupling back in the limelight
Caryl E. Hill
Thursday June 28th:
First Session: Endothelial calcium-activated potassium channels and vascular tone
Chairs: Ulrich Pohl – Michel Félétou
8h15 - 8h45 Introductory lecture:
Update on KCa3.1 (IK) and KCa2.3 (SK) channel pharmacology
Heike Wulff
8h45 - 9h10 Regulation of vascular tone and flow by endothelial KCa channels: from isolated cells to intact tissues Andrew P Braun
9h10 - 9h35 The role of EDHF in vasomotion – importance of the endoplasmic reticulum Christian Aalkjaer
9h35 - 10h00 Cardiovascular alterations in KCa3.1/KCa2.3 -deficient mice and after acute treatment with KCa3.1/KCa2.3 activators Ralf Köhler
10h00 - 10h25 Genetic deficit in SK3 and IK1 channels and development of hypoxic pulmonary hypertension in mice Ulf Simonsen
10h25 - 11h00 Coffee break  
Second Session: TRPV4 and the regulation of vascular tone
Chairs: Aimin Xu – Jo De Mey
11h00 -11h30 Introductory lecture:
Physiological implications for bi-directional communication at the neurovascular unit: role of TRPV4 channels
Jessica A Filosa
11h30 -11h55 Functional role of TRPV4-SKCa3 coupling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats Xiaoqiang Yao
11h55 -12h20 Vascular hypoxic-preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap-junctions communication, a protective role for EDHF? Geraldine Rath
12h20 - 14h15 Lunch and Poster viewing
Third Session: Arachidonic acid metabolism and vascular function
Chairs: Huang Yu – Robinson Joannides
14h15 -14h45
Introductory lecture:
Endothelial 15-lipoxygenase eicosanoids as EDHFs
William B. Campbell
14h45 -15h10
Not just EETs! Other cytochrome P450 products and the regulation of vascular function Ingrid Fleming
15h10 -15h35
Rhythmic expression of vasoactive compounds in the rat brain and cerebral vasculature David Harder
15h35 – 16h10 Coffee break  
Fourth Session: Extravascular signals and endothelial function
Chairs: Chris Triggle – Clinton Webb
16h10 - 16h40
Introductory lecture:
Endothelium-selective Activation of AMP-activated Protein Kinase Improves Re-endothelialization and Vascular Function Via Induction of Heme Oxygenase-1 in Diabetic Mice
Aimin Xu
16h40 - 17h05
Vasodilation of microvessels by the AMP-activated protein kinase (AMPK) involves activation of BKCa channels Ulrich Pohl
17h05 - 17h30
Hyperpolarizing and relaxing factors derived from perivascular adipose tissue: role of NO, H202 and adiponectin? Iris Egner
17h30 - 17h55
Putative role of cystathionine-γ-lyase–dependent H2S in endothelial vasodilation István A. Szijártó
19h00 - 20h00

Piano recital by Mr. Pascal Sigrist

Friday June 29th
Fifth Session: NO synthase and regulation of vascular function: NO but not just NO
Chairs: Ingrid Fleming – Nicole Villeneuve
8h30 - 9h00
Introductory lecture:
Attenuated EDHF-response underlies hypertension in redox-dead Cys42Ser PKGIɑ knock-in mouse
Oleksandra Prysyazhna
9h00 - 9h25
Evidence for the important role of the bone marrow in modulating microvascular endothelial and metabolic functions in mice Sota Nakajima
9h25 - 9h50
Nitrite- and nitroxyl-induced relaxation in porcine coronary (micro-) arteries: underlying mechanisms and role as endothelium-derived hyperpolarizing factor(s) Wendy W. Batenburg
9h50 - 10h30 Coffee break  
Sixth Session: Endothelial dysfunction
Chairs: Ricky YK Man – Gill Edwards
10h30 - 11h00
Introductory lecture:
Bone morphogenic protein-4 impairs endothelial function
Yu Huang
11h00 - 11h25
Targeted disruption of T-type calcium channels attenuate NO-dependent recovery after depolarization Pernille BL Hansen
11h25 - 11h50
Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2 Yu Wang
11h50 - 14h00 Lunch and Poster viewing  
Seventh Session: EDHF-mediated responses in diseases
Chairs: Professor Agostino Virdis – Helena Parkington
14h00 - 14h30
Introductory lecture:
Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted
Sandra Davidge
14h30 - 14h55
Alterations in vasodilatory components of endothelium-dependent relaxation in uterine arteries from type II diabetic rats Styliani Goulopoulou
14h55 - 15h20
The contribution of endothelium-derived hyperpolarizing factor is decreased in mesenteric arteries from rats bred for low intrinsic running capacity Owen L. Woodman
15h20 - 15h45
Alteration of EDHF under hypoxia-reoxygenation and possible reversing methods Qin Yang
15h45 - 16h20 Coffee break  
Eighth Session: EDHF-mediated responses in diseases, therapeutic options?
Chairs: Michael Hill - Ralf Kohler
16h20 - 16h45
Antenatal melatonin on vascular function in normally grown, growth restricted & alcohol exposed sheep fetuses Helena C. Parkington
16h45 - 17h10
Grape-derived polyphenols persistently improve the aging-related endothelial dysfunction, particularly the EDHF component, in the rat mesenteric artery: role of ROS, SKCa, IKCa and the angiotensin system Cyril Auger
17h10 - 17h35
Chronic treatment with SKA-31, an activator of endothelial K+ channels, in a severe murine model of hypertension associated with stroke, aortic aneurysms and renal failure Michel Félétou
17h35 - 18h00
Inhibition of the calcium-activated KCa3.1 channel reduces Na+ accumulation and edema formation in the early stages of ischemic stroke Yi Je Chen


Saturday June 30th
  Rooms must be vacated after breakfast
Ninth Session: EDHF-mediated responses in human in vitro and in vivo
Chairs: Jean-Paul Vilaine - A.H. Jan Danser
9h00 - 9h30
Introductory lecture:
Epoxyeicosatrienoic acids contribute with altered NO and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension
Jérémy Bellien
9h30 - 9h55
Significance of EDHF in the human blood vessel Guo-Wei He
9h55 - 10h20
Intact endothelial and EDHF-responses in subcutaneous resistance arteries from gastric bypass patients Emil T. Brondum
10h20 - 10h55 Coffee break  
10h55 - 11h20
Differential effect of CYP-2C9-dependent pathway on vascular tone or fibrinolysis regulation in healthy humans and patients with essential hypertension Professor Agostino Virdis
11h20 - 11h40
General Discussion  
11h40 - 11h55 Concluding remarks:
EDHF: the future
Arthur H. Weston
  Poster removal
12h30 Lunch  
15h00 Bus Departure towards Paris (Porte Maillot)  

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