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| 20h30 - 20h45 |
Welcoming Remarks:
EDHF: past and present
|
Paul M. Vanhoutte |
| |
First Tudor Griffith lecture session
Chair:
Paul M Vanhoutte |
|
| 20h45 - 21h30 |
First Tudor Griffith lecture:
Tudor Griffith, gap junctions and conducted vasodilation: electromechanical coupling back in the limelight |
Caryl E. Hill |
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| First Session: |
Endothelial calcium-activated potassium channels and vascular tone
Chairs:
Ulrich Pohl – Michel Félétou |
| 8h15 - 8h45 |
Introductory lecture:
Update on KCa3.1 (IK) and KCa2.3 (SK) channel pharmacology |
Heike Wulff |
| 8h45 - 9h10 |
Regulation of vascular tone and flow by endothelial KCa channels: from isolated cells to intact tissues |
Andrew P Braun |
| 9h10 - 9h35 |
The role of EDHF in vasomotion – importance of the endoplasmic reticulum |
Christian Aalkjaer |
| 9h35 - 10h00 |
Cardiovascular alterations in KCa3.1/KCa2.3 -deficient mice and after acute treatment with KCa3.1/KCa2.3 activators |
Ralf Köhler |
| 10h00 - 10h25 |
Genetic deficit in SK3 and IK1 channels and development of hypoxic pulmonary hypertension in mice |
Ulf Simonsen |
| 10h25 - 11h00 |
Coffee break |
|
| Second Session: |
TRPV4 and the regulation of vascular tone
Chairs: Aimin Xu – Jo De Mey |
| 11h00 -11h30 |
Introductory lecture:
Physiological implications for bi-directional communication at the neurovascular unit: role of TRPV4 channels |
Jessica A Filosa |
| 11h30 -11h55 |
Functional role of TRPV4-SKCa3 coupling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats |
Xiaoqiang Yao |
| 11h55 -12h20 |
Vascular hypoxic-preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap-junctions communication, a protective role for EDHF? |
Geraldine Rath |
| 12h20 - 14h15 |
Lunch and Poster viewing
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|
| Third Session: |
Arachidonic acid metabolism and vascular function
Chairs: Huang Yu – Robinson Joannides |
14h15 -14h45
|
Introductory lecture:
Endothelial 15-lipoxygenase eicosanoids as EDHFs |
William B. Campbell |
14h45 -15h10
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Not just EETs! Other cytochrome P450 products and the regulation of vascular function |
Ingrid Fleming |
15h10 -15h35
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Rhythmic expression of vasoactive compounds in the rat brain and cerebral vasculature |
David Harder |
| 15h35 – 16h10 |
Coffee break |
|
| Fourth Session: |
Extravascular signals and endothelial function
Chairs: Chris Triggle – Clinton Webb |
16h10 - 16h40
|
Introductory lecture:
Endothelium-selective Activation of AMP-activated Protein Kinase Improves Re-endothelialization and Vascular Function Via Induction of Heme Oxygenase-1 in Diabetic Mice |
Aimin Xu |
16h40 - 17h05
|
Vasodilation of microvessels by the AMP-activated protein kinase (AMPK) involves activation of BKCa channels |
Ulrich Pohl |
17h05 - 17h30
|
Hyperpolarizing and relaxing factors derived from perivascular adipose tissue: role of NO, H202 and adiponectin? |
Iris Egner |
17h30 - 17h55
|
Putative role of cystathionine-γ-lyase–dependent H2S in endothelial vasodilation |
István A. Szijártó |
| 19h00 - 20h00 |
Piano recital by Mr. Pascal Sigrist |
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| |
| Fifth Session: |
NO synthase and regulation of vascular function: NO but not just NO
Chairs: Ingrid Fleming – Nicole Villeneuve |
8h30 - 9h00
|
Introductory lecture:
Attenuated EDHF-response underlies hypertension in redox-dead Cys42Ser PKGIɑ knock-in mouse |
Oleksandra Prysyazhna |
9h00 - 9h25
|
Evidence for the important role of the bone marrow in modulating microvascular endothelial and metabolic functions in mice |
Sota Nakajima |
9h25 - 9h50
|
Nitrite- and nitroxyl-induced relaxation in porcine coronary (micro-) arteries: underlying mechanisms and role as endothelium-derived hyperpolarizing factor(s) |
Wendy W. Batenburg |
| 9h50 - 10h30 |
Coffee break |
|
| Sixth Session: |
Endothelial dysfunction
Chairs: Ricky YK Man – Gill Edwards |
10h30 - 11h00
|
Introductory lecture:
Bone morphogenic protein-4 impairs endothelial function |
Yu Huang |
11h00 - 11h25
|
Targeted disruption of T-type calcium channels attenuate NO-dependent recovery after depolarization |
Pernille BL Hansen |
11h25 - 11h50
|
Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2 |
Yu Wang |
| 11h50 - 14h00 |
Lunch and Poster viewing |
|
| Seventh Session: |
EDHF-mediated responses in diseases
Chairs: Professor Agostino Virdis – Helena Parkington |
14h00 - 14h30
|
Introductory lecture:
Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted |
Sandra Davidge |
14h30 - 14h55
|
Alterations in vasodilatory components of endothelium-dependent relaxation in uterine arteries from type II diabetic rats |
Styliani Goulopoulou |
14h55 - 15h20
|
The contribution of endothelium-derived hyperpolarizing factor is decreased in mesenteric arteries from rats bred for low intrinsic running capacity |
Owen L. Woodman |
15h20 - 15h45
|
Alteration of EDHF under hypoxia-reoxygenation and possible reversing methods |
Qin Yang |
| 15h45 - 16h20 |
Coffee break |
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| Eighth Session: |
EDHF-mediated responses in diseases, therapeutic options?
Chairs: Michael Hill - Ralf Kohler |
16h20 - 16h45
|
Antenatal melatonin on vascular function in normally grown, growth restricted & alcohol exposed sheep fetuses |
Helena C. Parkington |
16h45 - 17h10
|
Grape-derived polyphenols persistently improve the aging-related endothelial dysfunction, particularly the EDHF component, in the rat mesenteric artery: role of ROS, SKCa, IKCa and the angiotensin system |
Cyril Auger |
17h10 - 17h35
|
Chronic treatment with SKA-31, an activator of endothelial K+ channels, in a severe murine model of hypertension associated with stroke, aortic aneurysms and renal failure |
Michel Félétou |
17h35 - 18h00
|
Inhibition of the calcium-activated KCa3.1 channel reduces Na+ accumulation and edema formation in the early stages of ischemic stroke |
Yi Je Chen |
| 19:30 |
Dinner |
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| |
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Rooms must be vacated after breakfast |
| Ninth Session: |
EDHF-mediated responses in human in vitro and in vivo
Chairs: Jean-Paul Vilaine - A.H. Jan Danser |
9h00 - 9h30
|
Introductory lecture:
Epoxyeicosatrienoic acids contribute with altered NO and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension |
Jérémy Bellien |
9h30 - 9h55
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Significance of EDHF in the human blood vessel |
Guo-Wei He |
9h55 - 10h20
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Intact endothelial and EDHF-responses in subcutaneous resistance arteries from gastric bypass patients |
Emil T. Brondum |
| 10h20 - 10h55 |
Coffee break |
|
10h55 - 11h20
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Differential effect of CYP-2C9-dependent pathway on vascular tone or fibrinolysis regulation in healthy humans and patients with essential hypertension |
Professor Agostino Virdis |
11h20 - 11h40
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General Discussion |
|
| 11h40 - 11h55 |
Concluding remarks:
EDHF: the future
|
Arthur H. Weston |
| |
Poster removal
|
|
| 12h30 |
Lunch |
|
| 15h00 |
Bus Departure towards Paris (Porte Maillot) |
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